Lung carcinoma, well known as lung cancer, is the top cause of cancer related deaths all over the world. Research showed the incidence rates of women and men as 19.5% and 13% respectively (1,2). Since there is no symptom in its early stages, around 70% patients are diagnosed as lung cancer at advanced stage. In China, the 5-year survival rate of a patient at advanced stage is about 16% (3). However, the lung cancer could be cured effectively with great chance if it is diagnosed at an early stage rather than at an advanced stage, and the 5-year survival rate could rise to 70% (4). The early diagnosis of lung cancer, mainly rely on the detection of the lung nodule, also known as pulmonary nodule. To get a better method to detect nodules in early stage, the National Lung Screening Trial (NLST) research team did research on a large population of patients from different centers, whose results showed that high-risk smokers screened with low-dose computed tomography (LDCT) got less death by 20%, compared to those with thorax radiography (5). Furthermore, as recommended by Naidich et al. (6) and the American College of Radiology (ACR) (7), thin-slice computed tomography (CT) scans should be the first choice for the management of pulmonary nodules.
Therefore, CT scans as the most suitable modality to find the pulmonary nodules, are use more and more broadly by the radiologists nowadays. However, screening CT images manually is a very time-consuming job for radiologists, for there are hundreds of slices in one scan and there are less than 100 voxels in a single nodule usually. Advanced computer-aided detection systems (CADe) and computer-aided diagnosis systems (CADx) are likely to push such process on. However, this task is so complicated that, there are huge variation in shape, anatomical context, intensity and size between nodules. Besides, there are many non-nodules tissues similar to the appearance of nodules, such chest wall and vessels (8). Nodules can be categorized into three different kinds according to spatial locations, including juxta-pleural nodules, juxta-vascular nodules and solitary pulmonary nodules, On the other hand, based on their spatial patterns, they can be categorized into solid pulmonary nodules, part-solid pulmonary nodules and ground-glass pulmonary nodules. The CAD, including CADe and CADx, can help radiologists to find potential abnormalities. The accuracy of pulmonary nodule diagnosis will be improved by improving the radiologist’s efficiency.
Considerable research efforts have been devoted to pulmonary nodule detection on chest CT images, so as to segmentation and classification. It could be divided into non-learning based methods (9-12) and learning based methods (13). The non-learning based methods are usually experience driven and compute morphological features of the images that could well distinguish the target regions and background, i.e., nodule and vessels. The learning based methods are data driven and learn the optimal decision boundary in a high-dimensional feature space from a set of prepared labeled data to distinguish target and background. There are two obvious differences between these two methods: (I) need of data with annotation or not; (II) who define the distinguishing boundary or features. The non-learning based methods do not need annotated data, and the distinguishing features or boundary are totally manually defined. However, annotated data is necessary for learning based methods, which is regarded as training data. A typical learning based method composes of feature extraction and classifier, while the classifier need to be learned from the training data, and the features could be handcrafted or learned from the training data. The handcrafted features are defined manually, such as HOG (14), LBP (15), SIFT (16), that showed great advantage before deep learning. Deep learning techniques compose of many layers with different filers that learned from training data and used to transform the input to high-dimensional feature. Convolutional neural networks (CNNs) are the most successful type for image analysis.
The rest of paper is organized as follows. Available public datasets for pulmonary nodule related applications are shown in section 2. Section 3 presents a brief overview introduction of deep learning techniques. Section 4 presents the three main applications of pulmonary nodule, including detection, segmentation and classification.
Open dataset of pulmonary nodule
For case of lung cancer screening, the first trial was the Early Lung Cancer Action Program (ELCAP) that made the ELCAP Public Lung Image Database available in 2003. The database consists of 50 LDCT scans for the evaluation of CAD systems.
The NLST randomized 26,724 subjects to the CT screening arm of its two-arm study. A total of 48,547 scans were selected from among the 75,133 LDCT scans acquired from 33 participating institutions were archived in the CT Image Library (CTIL). As the most commonly used and largest publicly available dataset for early diagnosis of lung cancer, the Lung Image Database Consortium and Image Database Resource Initiative (LIDC-IDRI) involved 1,010 patient records gathered from University of Iowa, University of Chicago, University of California at Los Angeles, Weill Cornell Medical College and University of Michigan. LUNA16 dataset is a subset of LIDC-IDRI with detection annotation only.
In this section, LIDC-IDRI and LUNA16 are presented in details.
After the initialization by National Cancer Institute (NCI), the LIDC-IDRI was further constructed by Foundation for the National Institutes of Health (FNIH) and Food and Drug Administration (FDA). There are 1,018 CT scans of 1,010 patients enrolled in this dataset, each of which includes a thoracic CT scan and a corresponding XML file that recorded the annotated results finished by four professional radiologists. The annotation process composed of two phases, which aimed to recall as entirely as possible all nodules in each CT scan. In the first phase, named as blinded-read phase, each radiologist reviewed scans independently and marked lesions, such as “nodule <3 mm”, “nodule ≥3 mm”, and “non-nodule ≥3 mm”. In the subsequent phase, named as unblinded-read phase, each radiologist checked his own marks independently and made a final decision refer to anonymous marks of other radiologists. There are 7,371 lesions labeled as “nodule” by at least one radiologist inside the dataset; 2,669 of these lesions got at least one “nodule ≥3 mm” label from four radiologist, while 928 got four. Subjective nodule characteristic ratings and nodule outlines were involved in these 2,669 lesions.
The outline could describe the shape and size of nodule by localizing the outer border, which did not overlap pixels belonging to the nodule. If a nodule was marked as “nodule ≥3 mm” after two phases, its characteristics were assessed by radiologist, including internal structure, shape (sphericity), margin, solidity, lobulation, speculation, subtlety and likelihood of malignancy.
The LUNA16 dataset was created for the challenge of LUng Nodule Analysis 2016 including 888 CT scans, which were gathered from LIDC-IDRI with slice thickness less than 3mm. There are totally 36,378 annotations of nodules that were marked by more than one radiologists, while there are 2,290, 1,602, 1,186, and 777 nodules annotated by at least 1, 2, 3, or 4 radiologists, respectively. Nodules annotated by at least 3 radiologists are regarded as true nodules, whose annotations of diameters and positions are the average of annotation in LIDC-IDRI.
Overview of deep learning techniques
In this section, the deep learning technique is introduced, especially deep CNN. Generally, deep learning provides the potential to automate and merge the extraction of relevant features with the classification procedure (23-25). Recently, CNN has been shown to be very powerful in computer vision application and keep breaking the performance records in challenges (26,27). Specially, applications of medical image analysis have already leveraged CNN (28-30).
CNNs compose of many layers that transform their input with weights by convolutional operation. Research on CNNs has been started since the late seventies (31). The first successful real-world application of CNN is the LeNet (32) for recognition of hand-written digit. Krizhevsky et al. (26) proposed a CNN named AlexNet, and won the ImageNet Large Scale Visual Recognition Challenge (ILSVRC) in 2012 by a large margin. In the following years, there was large progress using related and innovated deeper architectures (27,33). Nowadays in computer vision, CNNs has become the first choice, even in many clinical applications.
Deep learning in pulmonary nodule application
Generally, there are three main applications of pulmonary nodule: detection, segmentation and classification. The detection module aims to predict the exact position of nodule inside the lung. The segmentation module aims to predict which voxels are nodule voxels. And the classification module could predict the exact type of nodule, i.e., benign or malignant.
In this section, researches with deep learning on these three applications are presents, while some non-deep learning methods are presented for comparison.
Generally, nodule detection contains two main stages: (I) nodule candidate generation; (II) false positive reduction (FPR). Nodule candidate generation is a basis stage, while FPR is an advanced stage to make the detection more precise. In this part, detection of pulmonary nodule is presented in two parts differing from using deep learning or not.
Detection with deep learning
The deep learning is furthermore to improve the ability to build the classification boundary from data, especially for big data. Ozdemir et al. (34) proposed a two-stage Bayesian CNN architecture, to leverage the segmentation predictions along with their uncertainties. First, segmentation networks operate on 2D axial CT slices. Then segmentation predictive mean and standard deviation maps are fused with the original image to form a 3-channel composite image, which is fed into a 3D Bayesian CNN for final nodule detection. Zhu et al. (19) integrated expectation-maximization (EM) to construct a new deep 3D CNN framework, named as DeepEM, whose aim was mining the weakly supervised labels in EMRs for pulmonary nodule detection. The nodule proposal generation was finished by Faster RCNN. Logistic regression and Half-Gaussian model are utilized for lobe location central slice respectively. In the E-step, all the slices, observations, and weak labels were employed to predict the nodule proposals, latent variable, by sampling or maximum a posteriori (MAP). In the M-step, parameters in logistic regression and Faster R-CNN were updated by using the estimated proposals. Xie (20) proposed a 3D U-Net leveraging residual and dense learning from ResNet and DenseNet (35) for pulmonary nodule detection. This method extended the region proposal network (RPN) in faster RCNN to 3D scheme with patch-based scanning. Dou et al. (36) integrated a set of 3D CNNs with different sizes of receptive field to involve multi-level contextual information around pulmonary nodules. Three different 3D CNNs are constructed for cropped cubes with different sizes, including 20×20×6, 30×30×10, 40×40×26. Three results are fused at last. Jiang et al. (37) propose a method for pulmonary nodule detection utilizing multi-group patches cut out from the lung images. First, Frangi-filters were used to eliminate the vessel-like structures, and a slope analysis method was designed to eliminate the nodule outside lung by repairing the juxta-pleural nodules. Finally, a CNN structure which utilized multi-crop (MC) pooling operation was designed to learn the knowledge of radiologists using original CT scans and its binarization.
FPR which could be regarded as classification of distinguishing nodule from non-nodule is a single topic that receives attention from researchers. Instead of using conventional convolutions, Winkels (38) proposed a FPR method from pulmonary nodule detection by using 3D roto-translation group convolutions (G-Convs). Its results showed that, it was more effective in sensitivity of malignant nodules, convergence speed than baseline architecture with similar number of parameters and regular convolutions. Golan et al. (39) proposed a sliding window based method to detect the nodules. A CNN for classification was trained with sub-volume of size 5×20×20 first. Then, it is applied to the whole CT scans using sliding window of shape as 5×20×20. The outputs of CNN in different sliding windows positions were averaged to compute the 3D voting grid, so as to predict the nodule’s location. Anirudh et al. (40) also proposed a sliding window based method but employed 3D CNN to learn more discriminative features for nodule detection. The 3D CNN was trained to infer the categories of a single voxel, that inside a nodule or not. 3D Hessian was used as FPR method for dot enhancement to get the most like nodule candidates. Khosravan et al. (41) modeled lung nodule detection as a cell-wise classification problem, done simultaneously for all the cells, and used a single feed forward pass of a single network for detection, namely S4ND. The pipeline is constructed as a 3D dense CNN with end-to-end training. The input scan is divided by a 16×16×8 grid and is passed through the S4ND. The output is a probability map indicating the presence of a nodule in each cell.
Furthermore, some researches combined nodule generating and FPR in one pipeline.
Xie et al. (42) proposed a 2D nodule detection and FPR method. Firstly, the Faster RCNN was used to detect nodule candidates, with two RPN and a deconvolutional layer for the middle three slices of the nodule respectively, while extra neighboring two slices were used as input for each. Secondly for FPR, a boosting architecture by 2D CNN is proposed. To further boost the sensitivity of detection, the model is retrained with the misclassified samples. At last, the final classification results are made by fusion of results of those networks. Ding et al. (21) proposed a nodule detection method composing of 2D candidate generation and 3D FPR. The method detects candidates on axial slices by Faster RCNN with a deconvolutional structure, and the input is not only a single slice but with neighboring slices. The 3 slices in axial direction were rescaled to 600×600×3 for input. Then in FPR, a 3D DCNN is used. Compared with 2D CNN, the 3D CNN can capture the candidate’s full range of contexts and extract more discriminative features. Dou et al. (22) proposed a nodule detection method including 3D CNN for candidate generation and FPR. To involve the size and location information, a hybrid-loss residual network was employed. In the candidate generation step, the 3D CNN was trained for classification of nodule and non-nodule with small 3D patches. To increase the ratio of hard samples, an online sample filtering method was used. To leverage both priori knowledge about lung nodules and machine learning, Huang et al. (43) used a local geometric-model-based filter to generate nodule candidates and further reduced the structure variability by estimating the local orientation. At last, a deep 3D CNN trained to classify nodule and non-nodule was used to classify the 3D cubes of nodule candidates. Zhang et al. (44) proposed a 3D progressive resolution-based densely dilated FCN, namely the progressive resolution network (PRN), to detect nodule candidates, and construct a densely dilated 3D CNN with hierarchical saliency, namely the hierarchical saliency network (HSN), for FPR. The PRN was constructed by a dual-path encoder and a decoder. In the encoder path, each input volumetric patch was enlarged to 64×64×64, then, feed the patch and its enlarged copy to two encoder paths, respectively. Each encoder path composes of convolutional layers, ReLU activation function and PRN blocks. The proposed HSN model consists of four subsequent HSN blocks. Each HSN block takes three volumetric patches as input, which are cropped on the chest CT scan according to the center of the detected nodule candidate. Tang et al. (8) proposed a nodule detection and FPR method. A 3D Faster RCNN inspired by Unet was proposed for nodule detection, which was trained with online hard negative mining. To extract detailed local information of the nodule, shortcuts from the end of each block to the last feature map were integrated to the 3D CNN classifier, which was used in FPR. The FPR classifier was trained on difficult examples produced during candidate generation. Sun et al. (45) used graph cuts segmentation to identify and segment the nodule candidates. And then, a CNN was utilized for FPR. Setio et al. (46) proposed a multi-view convolutional network, which comprises multiple streams of 2D CNN. Candidates by three detectors specifically designed for large nodules, solid and part-solid nodules were combined for input to the network. Each candidate is extracted 2D patches using nine views of a volumetric object, and go through corresponding stream. For the final classification, all outputs are combines using fusion method. Sakamoto et al. (47) proposed fusion classifier with the cascaded CNNs to classify nodule from non-nodules. Firstly, Nodule probabilities are calculated by CNN. Then the nodule probabilities were used to train the fusion classifier, which was also a deep CNN. The method operated as single-sided classifiers, filtering processes for obvious non-nodules. The input is a vector of the nodule probability of a nodule candidate generated from several CNN classifiers.
There is research focusing not only deep learning, but also leverage handcrafted features. Chen et al. (48) proposed three multi-task learning (MTL) schemes for the description of 9 semantic features of pulmonary nodule, which leveraged handcrafted HoG and Haar-like features, as well as features derived from deep learning models of CNN and stacked denoising autoencoder (SDAE).
Detection without deep learning
There are variable of research on pulmonary nodule detection before the rising trend of deep learning. Those non-deep learning methodologies mainly use morphological filers with thresholding method and traditional machine learning method compositing of handcrafted features and classifiers.
By leveraging the power of morphological filters, Teramoto et al. (9) utilized active contour filter to enhance lung regions, after that the nodules were extracted by thresholding. John and Mini (11) used intermediate thresholding to locate nodules. Then, the binary image mask and micro-level thresholding were combined to obtain the initial nodule candidates. Liu et al. (12) proposed a model matching method to detect nodules, namely selective enhancement filter. Hidden conditional random field (HCRF) was used to detect nodules for 3D representation stacked by 2D CT scans.
Compared with the morphological filters, machine learning based method could build the optimal boundary from data itself. A supervised extraction of the region of interest was proposed by Orozco et al. (49) to eliminate the differences of shape between CT images. Features from each wavelet sub-band are combined in pairs as input to a SVM, which is used to classify CT images with cancerous nodules or without. Santos et al. (50) segmented the structures in lung by Gaussian mixture models firstly. And then, discriminate nodule from non-nodule by texture descriptor as Shannon’s and Tsallis’s Q entropy. Besides, the Hessian matrix was used to separate bronchi and blood vessels, and reduced false positives by SVM. Lu et al. (51) proposed a hybrid method for nodule detection, integrating local density maximum algorithm, fuzzy connectedness (FC) segmentation, geodesic distance map, dot-enhancement based on Hessian matrix, regression tree classification, and orphological operation. Farahani et al. (52) proposed a nodule detection method with ensemble of three classifiers including SVM, KNN and MLP. Specific features like compactness, circularity, roundness, eccentricity and ellipticity are calculated from the segmented 2D images and used for classification for each classifier. Finally, majority voting method is used to combine decisions for the diagnosis of nodule. Klik et al. (53) used the linear discriminate analysis (LDA) classifier to distinguish nodules from candidates generated by segmentation using gray level characteristics and optimal thresholding. The LDA classifier was regarded as a FPR classifier using geometrical and gray level characteristics. Forz et al. (54) integrated SVM and texture features together and proposed a methodology to classify lung nodule and non-nodule (FPR). To extract the texture features, three techniques were involved: artificial crawlers (ACs), rose diagram (RD) and a hybrid model combining the RD and texture measurements from ACs. Finally, the SVM was employed with a radial basis kernel.Comparison of different detection methods of nodules is shown in Table 1. Because of different sorting methods for LIDC-IDRI dataset, it is hard to compare different methods evaluated on LIDC-IDRI. However, the 3D input data based methods achieved better performance than 2D and 2.5D based methods in general. Also, deep learning based methods outperform non-deep learning methods with larger training dataset and validation dataset. In the case of LUNA16, 3D CNN based method show obvious advantages compared with 2D or 2.5D based methods, while Zhang et al. achieved the best average recall of FROC with LUNA16 by a 3D CNN based method. The fact of better results by 3D based methods illustrates that the surrounding and texture of the nodules can be leveraged to facilitate the detection of nodule.
The segmentation of nodules in CT scans allows quantitative analysis of clinical parameters related to shape, volume and distribution of voxel values.
Segmentation with deep learning
For the segmentation with deep learning, some research regarded the segmentation mission as a classification mission voxel by voxel. Wang et al. (55) developed a multi-view convolutional neural networks (MV-CNN) for nodule segmentation to distinguish voxel by voxel if it is belonging to nodule or not. The proposed MV-CNN composed of three CNN branches, each of which takes multi-scale nodule patches from sagittal, coronal and axial views as input. A fully connected layer was applied to integrate the three CNN branches, to infer whether the voxel in patch center is nodule. Besides MV-CNN, Wang et al. (56) proposed another model, namely the central focused convolutional neural networks (CF-CNN), to segment lung nodules as classification voxels by voxels. Both multi-scale 2D features and 3D features were leveraged in a two-branch CNN. The branch of 2D-patch learns multi-scale features from multiple 2D patches, and the branch of 3D-patch learns multi-view features from multiple CT slices. To facilitate the training of model, a weighted sampling was employed to select training samples refer to the difficulty of segmentation. Trial of combining deep learning and non-deep learning has been made. Mukherjee et al. (57) hypothesize that combining both model based strategies and data driven in one hybrid approach could be more suitable for the complicate task of pulmonary nodules segmentation. An energy minimization based segmentation framework deep learned prior based graph cut (DLGC) was proposed, which combines a domain specific cost function using low level image features and a deep learned object localization. The combination of machine learned prior and unsupervised image based component makes it robust to initialization errors with higher flexibility.
Segmentation without deep learning
For segmentation of pulmonary nodules without deep learning, there are several specific methodologies, such as active contour, fuzzy related methods. Nithila and Kumar (58) developed a fuzzy c-means (FCM) and region based active contour model technique for segmentation of lung nodules. Reconstruction of lung parenchyma is operated by Gaussian filtering and selective binary with new signed pressure force function (SBGF-new SPF). And nodule segmentation was finished by clustering technique. Aresta et al. (10) used three methods including refined morphological, active contours and region-growing to segment nodules. Badura and Pietka (59) proposed a multilevel method to segment the pulmonary nodules in CT scans. The FC is first used to generate the masks, especially for the nodules connected to the vessels or pleura. Then evolutionary computation is utilized to improve the FC analysis and its accuracy. Gonçalves et al. (60) proposed a nodule segmentation approach using Hessian-based strategies. It is a multiscale process, which uses a Hessian-based strategy and the central medialness adaptive principle.
Table 2 shows the comparison of different segmentation methods, whose methods are evaluated on LIDC-IDRI. There are different sorting methods of dataset and evaluation parameters, and we refer to the Dice coefficient as standard here. The 2.5D based methods by Wang et al. achieved the best dice, which used a novel method called central pooling in CNN. The pooling process by central pooling can focus on the nodule and make the feature map after pooling more effective. Otherwise, the non-deep learning based methods do not use Dice coefficient for evaluation, it is hard to tell which is better in related methods.
Generally, to classify a nodule in a CADx system may comprise three components: (I) nodule detection; (II) nodule segmentation; (III) feature extraction from nodule candidates; and (IV) classification of the candidate as benign or malignant based on its extracted features.
The main mission in nodule classification is the distinguishing of benign and malignancy.
Classification with deep learning
Cheng et al. (61) proposed a stacked denoising auto-encoder (SDAE) to discriminate benign nodules from malignant nodules. Buty et al. (62) proposed to combine features of nodule 3D shape and appearance to predict the malignancy. Nodule shape was modeled from radiologist’s binary nodule segmentations and parameterized using spherical harmonics (SH). The proposal combined three orthogonal patches of each nodule as one image input for the DCNN, and extracted the appearance features from the first fully-connected layer. A random forest classifier was used to predict the nodule malignancy based on the combining of both sets of features. Hussein et al. (63) propose a multi-view CNN for nodule characterization of malignancy. Three 2D patches corresponding to each dimension were concatenated to form a 3D tensor. The features of the input image were extracted by the network and then a Gaussian process (GP) regression was used for prediction of malignancy score. Dey et al. (64) proposed four two-pathway CNN to predict the malignancy of nodule, including a 3D DenseNet, a novel multi-output network, a basic 3D CNN and an augmented 3D DenseNet with multi-outputs. Each network has two pathways with 3D inputs of different scales. Based on the evaluation of LIDC-IDRI dataset, the 3D multi-output DenseNet achieves better classification accuracy. Wu et al. (65) proposed an interpretable and MTL CNN to predict the malignancy of pulmonary nodules, namely joint learning for pulmonary nodule segmentation attributes and malignancy prediction (PN-SAMP). Besides prediction of malignancy, the areas of detected nodules and the semantic high-level attributes could be provided. The image patches of two different window centers and window widths are stacked together as the input to the CNN. Shen et al. (66) presented a 3D interpretable deep hierarchical semantic CNN (HSCNN) to predict the malignancy of a nodule. There are two levels of output: (I) low-level radiologist semantic features; and (II) a high-level malignancy prediction score. The low-level task predicts five semantic diagnostic features: margin, texture, sphericity, subtlety, and calcification. The high-level task incorporates information from both the generalizable image features and the low-level tasks to produce an overall prediction of malignancy. Shen et al. (67) built an end-to-end machine-learning framework for malignancy classification of pulmonary nodule, named as multi-crop convolutional neural network (MC-CNN). To automatically extract nodule salient information, a MC pooling strategy cropping different regions from convolutional feature maps was employed and max-pooling was applied different times for each other. After the last fully connected layers, the features were concatenated together for classification. Hussein et al. (68) proposed a MTL to perform joint learning of tasks, such as malignancy, sphericity, spiculation, lobulation, texture, margin and calcification. Seven 3D CNN was fine-tuned using labels of those 7 attributes respectively. The features by the first fully connected layer in each model were utilized as feature representation. Graph regularized sparse least square optimization function was used to fuse features from different CNNs and got the coefficient vectors corresponding to each task. In the testing phase, feature representation of the testing image with the coefficient vector was multiplied to obtain the malignancy score.
It is easy to say that, a fully automatic CADx system could not rely on single classification, and detection is necessary beforehand. Zhu et al. (69) proposed a method combining detection and classification (benign or malignant) named as DeepLung. Two deep 3D dual path networks (DPN) are designed for nodule detection and classification respectively. For nodule detection, a 3D faster RCNN with a U-net-like encoder-decoder structure and 3D dual path blocks was designed. For nodule classification, gradient boosting machine (GBM) with 3D DPN features is proposed. Liao et al. (70) proposed a method for detection and classification (benign or malignant), which won the Data Science Bowl 2017 (DSB2017). For the nodule detection, a 3D RPN with backbone of modified U-net was proposed. And for the classification, the top five nodules were selected based on the detection confidence, evaluates their cancer probabilities and combines them with a leaky noisy-or gate to obtain the probability of lung cancer for the subject, which share the same backbone as detection
Besides the malignancy, there is effort on types of nodule. Zhang et al. (71) proposed a semi-supervised classification method for four types of lung nodules, including pleural tail, vascularized, well-circumscribed and juxta-pleura. There were two steps in the proposal: (I) construction of bipartite graph, which showed the similar relationship between unlabeled and labeled images; (II) calculation of ranking score, which calculated the probability of unlabeled images for each type.
Classification without deep learning
Shen et al. (72) proposed a hierarchical learning framework for nodule classification of benign or malignancy, named as MC-CNN. The method extracted features from alternatingly stacked layers, so as to capture the nodule heterogeneity. Klik et al. (53) proposed a non-deep learning method to distinguish perifissural opacities (PFOs) from potentially malignant nodules. The proposal leveraged two characteristic properties of PFOs for classification, including its attachment to plate-like structures in the direct neighborhood of the nodule (the lung fissures) and the typical flattened surface.
Classification methods shown in Table 3 are all deep learning based methods, with training dataset mainly from LIDC-IDRI, except one from DSB2017. Methods with 3D input outperform 2.5D input in LIDC-IDRI dataset, and achieved the best accuracy as high as 97.58%. The accuracy of the 2D input methods by Cheng et al. is 94.4%, and outperforms most of other methods, except the 3D input methods by Wu et al. It also shows the surrounding and texture of the nodules can be leveraged to facilitate the classification of nodule.
This paper presented a survey of automatic CADe and CADx for detection, segmentation and classification of pulmonary nodule on CT scans. The cited papers are mainly gathered from popular academic journals and conferences, which were published in recent years. As the fast-growing in deep learning techniques and break-through performance, variables of deep learning-based methodologies whose results show great advantage have been proposed for these three missions as well as non-deep learning ones. In most research, deep learning is leveraged to solve or improve a single mission. However, several multi-tasks work combining detection and classification are done. In some deep learning-based works, non-deep learning method is involved to boost its ability, and the results show solid evidence. There are efforts to expedite the progress of research on pulmonary nodules, such as more and more available open dataset and challenges. It is generous to make effort to build the open available dataset, because it is really a complicate hard job to collect the data and annotate it by doctors, and it can really help researcher to push on their research and validate their ideas. And well known challenges as Data Science Bowl 2017 and LUNA 2016 were held which provided a stage for knowledge sharing rather than competition. In some case, proposed methods have reached even exceed radiologists’ level. However, there is a significant problem for all learning-based methods that is generalization ability. It is due to the diversity of training dataset and the methods itself. As a conclusion, deep learning has made great impact on the applications of pulmonary nodule, and we believe that it will be a more powerful methodology in the future.
It is so appreciated for support and help from workmates in the project of Miying in Tencent.
Conflicts of Interest: J Wu and T Qian are Tencent employees.
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Cite this article as: Wu J, Qian T. A survey of pulmonary nodule detection, segmentation and classification in computed tomography with deep learning techniques. J Med Artif Intell 2019;2:8.